How vitamin K affects blood clotting and other body functions
Mechanisms controlling the efficiency of hemostatic vitamin K-dependent protein activation
This study is looking at how vitamin K helps your body activate important proteins for blood clotting and how medications like warfarin can affect this process, with the goal of finding ways to improve treatments for people who need help managing their blood health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10817732 on NIH RePORTER |
What this research studies
This research investigates how dietary vitamin K is used in the body to activate proteins that are crucial for blood clotting and other physiological processes. It focuses on the mechanisms by which vitamin K-dependent proteins are formed and how their activation can be influenced by medications like warfarin, which is commonly prescribed to manage blood clotting. By understanding these processes, the research aims to uncover the broader implications of vitamin K in health and disease, particularly in relation to coagulation and inflammation. Patients may benefit from insights that could improve anticoagulant therapies and overall health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients who are on anticoagulant medications, particularly those using warfarin for blood clotting management.
Not a fit: Patients who do not use anticoagulant medications or have no issues related to blood clotting may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients requiring anticoagulation therapy, enhancing their safety and effectiveness.
How similar studies have performed: Previous research has shown promising results in understanding vitamin K's role in coagulation, suggesting that this approach could yield significant insights.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Berkner, Kathleen Lucile — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Berkner, Kathleen Lucile
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.