How vitamin A is processed in the lungs of adults
Official title: Vitamin A metabolism in the adult lung
Funded at Rutgers, the State Univ of N.j. · NIH-10997364 · Data updated 2026-11-12
This study is looking at how vitamin A works in the lungs and how it gets to lung cells, which could help us understand its role in lung health, especially when dealing with lung injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $573,946 |
| NIH project number | 5R01HL171112-02 |
| Project ID | NIH-10997364 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are at risk for or suffering from acute lung injury.
✕Less likely to help
Patients with chronic lung conditions unrelated to vitamin A metabolism may not benefit from this research.
What this research studies
This research investigates the metabolism of vitamin A in the lungs, focusing on how it is delivered and utilized by lung cells. The study challenges existing beliefs by exploring a new pathway for vitamin A delivery via lipoproteins rather than solely through the liver. Using advanced techniques like single-cell RNA sequencing, the researchers aim to understand the role of different lung cell types in vitamin A storage and transport. The findings could reveal critical insights into how vitamin A affects lung health, particularly in the context of acute lung injury.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating acute lung injuries by optimizing vitamin A metabolism in the lungs.
How similar studies have gone: While the specific approach of investigating vitamin A metabolism in the lungs is novel, related research on vitamin A's role in lung health has shown promising results.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: Shmarakov, Igor — Rutgers, the State Univ of N.j.
- Study coordinator: Shmarakov, Igor
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.