How vitamin A is processed in the lungs of adults
Vitamin A metabolism in the adult lung
['FUNDING_R01'] · RUTGERS, THE STATE UNIV OF N.J. · NIH-10997364
This study is looking at how vitamin A works in the lungs and how it gets to lung cells, which could help us understand its role in lung health, especially when dealing with lung injuries.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS, THE STATE UNIV OF N.J. (nih funded) |
| Locations | 1 site (PISCATAWAY, UNITED STATES) |
| Trial ID | NIH-10997364 on ClinicalTrials.gov |
What this research studies
This research investigates the metabolism of vitamin A in the lungs, focusing on how it is delivered and utilized by lung cells. The study challenges existing beliefs by exploring a new pathway for vitamin A delivery via lipoproteins rather than solely through the liver. Using advanced techniques like single-cell RNA sequencing, the researchers aim to understand the role of different lung cell types in vitamin A storage and transport. The findings could reveal critical insights into how vitamin A affects lung health, particularly in the context of acute lung injury.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are at risk for or suffering from acute lung injury.
Not a fit: Patients with chronic lung conditions unrelated to vitamin A metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating acute lung injuries by optimizing vitamin A metabolism in the lungs.
How similar studies have performed: While the specific approach of investigating vitamin A metabolism in the lungs is novel, related research on vitamin A's role in lung health has shown promising results.
Where this research is happening
PISCATAWAY, UNITED STATES
- RUTGERS, THE STATE UNIV OF N.J. — PISCATAWAY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHMARAKOV, IGOR — RUTGERS, THE STATE UNIV OF N.J.
- Study coordinator: SHMARAKOV, IGOR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Lung Injury, Acute Pulmonary Injury