How vitamin A affects the risk of tuberculosis progression and prevention
Official title: Mechanisms of vitamin A-dependent risk for tuberculosis progression and prevention
Funded at Colorado State University · NIH-11094803 · Data updated 2026-11-12
This study is looking at how vitamin A affects tuberculosis (TB) and whether getting enough of it can help prevent the disease, especially for people in communities where malnutrition is common.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project start | June 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $732,939 |
| NIH project number | 5R01AI162746-03 |
| Project ID | NIH-11094803 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for tuberculosis, especially those with known vitamin A deficiency or malnutrition.
✕Less likely to help
Patients who are not at risk for tuberculosis or who have adequate vitamin A levels may not benefit from this research.
What this research studies
This research investigates the role of vitamin A in the progression and prevention of tuberculosis (TB), a leading cause of infectious disease mortality. It aims to understand how vitamin A deficiency increases the risk of developing active TB and how it influences the immune response to the disease. The study will explore the mechanisms by which vitamin A contributes to immunity, particularly in malnourished communities that are at higher risk for TB. By examining these relationships, the research seeks to identify new prevention and treatment strategies for TB.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies and treatments for tuberculosis, particularly in populations with vitamin A deficiency.
How similar studies have gone: Previous research has indicated a link between vitamin A deficiency and increased risk of tuberculosis, suggesting that this approach has potential for meaningful insights.
Where this research is happening
-
Colorado State University
Fort Collins, United States Active
Researchers
- Principal investigator: Podell, Brendan — Colorado State University
- Study coordinator: Podell, Brendan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.