How viruses evade the body's immune response
Understanding evasion of cell intrinsic innate immunity in viral populations with high rates of replicative failure
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11092912
This study is looking at how the flu virus tricks our body's natural defenses so it can cause more harm, especially in people who might not respond well to infections, and it aims to help us understand why some folks get sicker than others.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11092912 on ClinicalTrials.gov |
What this research studies
This research investigates how certain viruses, particularly influenza A, manage to evade the body's innate immune system, which is crucial for detecting and responding to infections. The study focuses on the mechanisms by which these viruses suppress the production of signaling proteins called interferons, which are essential for initiating anti-viral responses. By understanding these processes, researchers aim to uncover why some individuals are at higher risk of severe complications from viral infections, especially those with defects in their interferon pathways. The research employs advanced modeling techniques to analyze viral populations and their interactions with the immune system.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with known defects in their interferon pathways or those who have experienced severe complications from viral infections.
Not a fit: Patients with robust immune responses and no history of complications from viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for patients at high risk of severe viral infections.
How similar studies have performed: Previous research has shown success in understanding viral evasion strategies, but this specific approach to studying influenza A's interaction with innate immunity is relatively novel.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RUSSELL, ALISTAIR B — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: RUSSELL, ALISTAIR B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute infection, Disease, Disorder