How viruses disrupt the host's gene expression
Official title: Viral disruption of host transcriptome integrity
Funded at New York University School of Medicine · NIH-11006252 · Data updated 2026-11-12
This study looks at how the herpes virus changes the way our cells work to help itself grow, focusing on a specific viral protein, and it aims to find new ways to treat infections caused by this virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $500,146 |
| NIH project number | 5R01AI170583-03 |
| Project ID | NIH-11006252 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals infected with herpes simplex virus type 1 or those at risk of such infections.
✕Less likely to help
Patients who are not infected with HSV-1 or do not have a history of viral infections may not benefit from this research.
What this research studies
This research investigates how viral infections, specifically herpes simplex virus type 1 (HSV-1), alter the expression of host genes to create favorable conditions for viral replication. The study focuses on the mechanisms by which the virus suppresses the host's protein synthesis and disrupts the normal processes of mRNA production and stability. By examining the role of a viral protein called ICP27, the research aims to uncover the specific ways in which the virus manipulates the host's cellular machinery. This could lead to a better understanding of viral infections and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating viral infections by targeting the mechanisms viruses use to hijack host cellular processes.
How similar studies have gone: Previous research has shown success in understanding viral manipulation of host cellular processes, making this approach a continuation of established findings.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Wilson, Angus C — New York University School of Medicine
- Study coordinator: Wilson, Angus C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.