How viruses change the structure of cell organelles to help them infect cells
Dynamic virus-driven remodeling of ER-mitochondria contacts
This study looks at how viruses change the way important parts of our cells work together, which could help us understand viral infections better and find new ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project ID | NIH-10890025 on NIH RePORTER |
What this research studies
This research investigates how viruses manipulate the interactions between cellular organelles, specifically focusing on the connections between the endoplasmic reticulum and mitochondria. By using advanced techniques like quantitative proteomics and super-resolution microscopy, the study aims to uncover the mechanisms by which viruses, such as cytomegalovirus, alter organelle structures to enhance their own survival and replication. Patients may benefit from insights gained into viral infections and potential therapeutic targets that could improve treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with cytomegalovirus or other related viral infections.
Not a fit: Patients who are not infected with any viruses or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating viral infections by targeting the ways viruses manipulate cellular structures.
How similar studies have performed: Other research has shown success in understanding viral manipulation of cellular processes, but this specific focus on organelle remodeling is relatively novel.
Where this research is happening
Princeton, UNITED STATES
- Princeton University — Princeton, United States (Active)
Researchers
- Principal investigator: Cristea, Ileana M. — Princeton University
- Study coordinator: Cristea, Ileana M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.