How viruses change cell processes to cause infections
Viral modulation of epitranscriptomic mechanisms
This project explores how viruses, like Adenovirus, alter the chemical tags on our cells' RNA to help them multiply and overcome our body's defenses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11074652 on NIH RePORTER |
What this research studies
Our cells have tiny chemical tags on their RNA, called PTrMs, which are important for how our cells work and fight off infections. Viruses, such as Adenovirus, are very clever and can change these tags to their advantage, helping them to grow and spread. This research uses advanced techniques to look closely at these changes in viral and human RNA. By understanding how viruses manipulate these processes, we hope to find new ways to stop them from causing illness. This work could lead to better treatments for viral infections, especially those affecting the airways.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit those affected by viral infections, particularly Adenovirus and airway infections, in the future.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for developing antiviral treatments that target how viruses manipulate our cells' RNA.
How similar studies have performed: While the field of epitranscriptomics is emerging, this project uses novel high-throughput technologies to explore how viruses manipulate these mechanisms, building on initial findings.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Garcia, Benjamin a — Washington University
- Study coordinator: Garcia, Benjamin a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.