How viruses affect the sense of smell and speed up Alzheimer's disease
Official title: Virus and olfactory system interactions accelerate Alzheimer's disease pathology
Funded at University of Colorado Denver · NIH-11012303 · Data updated 2026-11-12
This study is looking at how certain viruses might speed up Alzheimer's disease by affecting the sense of smell, and it's inviting people to help by sharing samples or taking part in tests about their smell and thinking abilities.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | May 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $947,968 |
| NIH project number | 5R01AG079193-03 |
| Project ID | NIH-11012303 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are individuals aged 65 and older who may be at risk for Alzheimer's disease or have early symptoms.
✕Less likely to help
Patients under the age of 65 or those without any risk factors for Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the role of certain viruses, specifically alphaherpesviruses, in accelerating the progression of Alzheimer's disease (AD). It focuses on how these viruses may disrupt the olfactory system, which is linked to cognitive decline and neurodegeneration. By examining the interactions between these viruses and the brain's olfactory pathways, the study aims to identify potential risk factors and mechanisms that contribute to AD. Patients may be involved in providing samples or participating in assessments related to smell and cognitive function.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for slowing the progression of Alzheimer's disease by targeting viral infections.
How similar studies have gone: Previous research has indicated a connection between viral infections and Alzheimer's disease, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Restrepo, Diego — University of Colorado Denver
- Study coordinator: Restrepo, Diego
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.