How viral genetic differences affect disease outcomes in newborns
The impact of viral genomic variation on neonatal disease outcomes
This study is looking at how different types of the herpes virus can affect newborns in different ways, helping us understand why some babies get really sick while others don’t, so we can find better ways to care for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project ID | NIH-11007200 on NIH RePORTER |
What this research studies
This research investigates how variations in the herpes simplex virus (HSV) can lead to different health outcomes in newborns. By analyzing viral genetic data and clinical information, the study aims to understand why some infants experience severe complications, such as central nervous system infections, while others have milder symptoms. The researchers will use a combination of genomic analysis, laboratory models, and clinical data to explore these connections. This work could help identify risk factors for severe disease and improve treatment strategies for affected infants.
Who could benefit from this research
Good fit: Ideal candidates for this research include newborns diagnosed with herpes simplex virus infections, particularly those showing severe symptoms.
Not a fit: Patients who are older than four weeks or those without herpes simplex virus infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment of herpes simplex virus infections in newborns, potentially reducing mortality and long-term health issues.
How similar studies have performed: Previous research has indicated that genetic variations in viruses can influence disease severity, suggesting that this approach may yield valuable insights.
Where this research is happening
University Park, United States
- Pennsylvania State University, the — University Park, United States (Active)
Researchers
- Principal investigator: Szpara, Moriah — Pennsylvania State University, the
- Study coordinator: Szpara, Moriah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.