How viral and immune treatments affect early HIV infection in the mouth
Official title: Influence of viral and immune interventions on early events following oral SIV infection
Funded at Seattle Children's Hospital · NIH-10996126 · Data updated 2026-11-12
This study is looking at how HIV spreads through the mouth, especially in babies born to moms with HIV and during oral sex, to find better ways to prevent infection by testing a new vaccine that goes directly into the mouth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 15, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $797,333 |
| NIH project number | 5R01DE032663-03 |
| Project ID | NIH-10996126 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include infants born to HIV-positive mothers and individuals at risk of HIV transmission through oral contact.
✕Less likely to help
Patients who are not at risk of HIV infection or those who are already HIV-positive may not benefit from this research.
What this research studies
This research investigates how HIV is transmitted through oral mucosal surfaces, particularly focusing on infants born to HIV-positive mothers and through oral sexual contact. It aims to understand the early events of HIV infection by using innovative techniques to deliver a vaccine directly into the oral mucosa, which may help in identifying where and how the virus enters the body. By studying the immune response in draining lymph nodes after this vaccine delivery, the research seeks to improve prevention strategies against HIV transmission. This approach could lead to better understanding and potentially new interventions for those at risk of HIV infection.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for HIV transmission, particularly in vulnerable populations such as infants.
How similar studies have gone: Other research has shown promise in using innovative vaccine delivery methods for HIV prevention, indicating potential for success in this approach.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Sodora, Donald L — Seattle Children's Hospital
- Study coordinator: Sodora, Donald L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.