How Vibrio cholerae interacts with the gut microbiome and responds to stress
Vibrio cholerae antinitrosative stress defenses and gut microbiome interaction
This study looks at how the cholera-causing germ interacts with the good bacteria in our gut and how it deals with the body's immune response, which could help us find better ways to treat cholera.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10908338 on NIH RePORTER |
What this research studies
This research investigates how the bacterium Vibrio cholerae, which causes cholera, interacts with the gut microbiome and responds to stress from the host's immune system. The study focuses on the role of nitric oxide and related compounds produced by the host during infection, examining how these factors affect the bacterium's ability to colonize the intestines. By using animal models, researchers aim to understand the complex interactions between the pathogen and the gut microbiome, which could lead to new insights into cholera infection and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in areas affected by cholera, particularly those with a history of gastrointestinal infections.
Not a fit: Patients who do not live in cholera-endemic regions or those who have not been exposed to Vibrio cholerae may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cholera and better understanding of gut health.
How similar studies have performed: Previous research has shown that understanding host-pathogen interactions can lead to significant advancements in treating infectious diseases, suggesting potential success for this approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Zhu, Jun — University of Pennsylvania
- Study coordinator: Zhu, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.