How Vibrio cholerae adapts to its environment
Environmental adaptation by Vibrio cholerae
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11038035
This study looks at how the cholera-causing germ, Vibrio cholerae, changes and survives in water environments, with the goal of finding new ways to treat or prevent cholera for people who might get sick from it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11038035 on ClinicalTrials.gov |
What this research studies
This research investigates how the bacterium Vibrio cholerae, which causes cholera, adapts to different environmental conditions, particularly in aquatic ecosystems. By examining the mechanisms that allow this pathogen to survive and thrive, the study aims to uncover how it interacts with its surroundings and how it can be combated. The research focuses on understanding the role of specific metabolites and signaling processes that influence the bacterium's virulence and ability to cause disease. Patients may benefit from insights gained that could lead to new treatments or preventive measures against cholera.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in areas where cholera is endemic or those who have been exposed to contaminated water sources.
Not a fit: Patients who do not live in cholera-affected regions or who have not been exposed to Vibrio cholerae may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel strategies for preventing and treating cholera, potentially saving lives.
How similar studies have performed: Previous research has shown success in understanding bacterial adaptation mechanisms, suggesting that this approach may yield valuable insights.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BINA, JAMES EDWARD — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: BINA, JAMES EDWARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.