How very slow brain activity shapes thinking, attention, and mood

Neurobiology and Cognitive Role of Slow Brain Network Fluctuations

NIH-funded research Nathan S. Kline Institute for Psych Res · NIH-11349765

This project looks at how very slow changes in brain activity affect attention, mood, and everyday thinking in adults.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionNathan S. Kline Institute for Psych Res NIH-funded
Lab location1 site (Orangeburg, United States)
Project IDNIH-11349765 on NIH RePORTER

What this research studies

You would be asked to do attention and thinking tasks while researchers record slow brain activity, heart rate, and pupil changes using tools like EEG and MRI. They will link seconds-to-tens-of-seconds fluctuations in large brain networks to moments when your mind drifts off-task or stays focused. Some experiments test whether these slow patterns predict reaction times, mood, and bodily responses, and may include lab-based manipulations or recordings. The goal is to learn when off-task thinking helps or harms behavior and mental health.

Who could benefit from this research

Good fit: Adults aged 21 and older who can complete cognitive tasks and tolerate brain recordings (EEG or MRI) and physiological monitoring are ideal candidates.

Not a fit: People under 21, those who cannot undergo brain scans or prolonged testing, or those seeking immediate treatment effects may not benefit from participating.

Why it matters

Potential benefit: If successful, this work could identify brain signatures that predict attention lapses and mood changes, guiding new ways to improve focus and mental wellbeing.

How similar studies have performed: Prior studies have linked mind-wandering and slow neural signals to attention and bodily responses, but testing the causal role of ultra-slow brain fluctuations is relatively new.

Where this research is happening

Orangeburg, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.