How variations in D2 receptors affect kidney health in older adults
Official title: D2 receptor variation and renal dysfunction
Funded at George Washington University · NIH-11004989 · Data updated 2026-11-12
This study is looking at how certain genes related to dopamine might affect kidney health and blood pressure in people aged 65 and older, especially how salt and sodium in their diet play a role, to find ways to help those at risk of kidney problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Washington University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | January 20, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $706,010 |
| NIH project number | 5R01DK134574-03 |
| Project ID | NIH-11004989 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who have a history of hypertension or chronic kidney disease.
✕Less likely to help
Patients under the age of 65 or those without any history of hypertension or kidney issues may not benefit from this research.
What this research studies
This research investigates the relationship between dopamine type 2 receptor (D2R) variations and kidney dysfunction, particularly in individuals aged 65 and older. It focuses on how salt sensitivity and sodium intake impact hypertension and chronic kidney disease (CKD). By examining genetic factors and their influence on kidney health, the study aims to identify potential interventions that could improve outcomes for those at risk. Patients may be monitored for changes in kidney function and blood pressure in relation to their sodium intake and genetic makeup.
Why it matters
Potential benefit: If successful, this research could lead to personalized dietary recommendations that improve kidney health and reduce the risk of chronic diseases in older adults.
How similar studies have gone: Previous studies have shown that genetic variations can influence kidney health, suggesting that this research could build on established findings.
Where this research is happening
-
George Washington University
Washington, United States Active
Researchers
- Principal investigator: Jose, Pedro a. — George Washington University
- Study coordinator: Jose, Pedro a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.