How vagal sensory neurons communicate about inflammation
Encoding of inflammatory mediators by vagal sensory neurons
This study is looking at how certain nerves in your body help communicate with your immune system when there's inflammation, which could help us understand better how to manage conditions related to inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project ID | NIH-11100204 on NIH RePORTER |
What this research studies
This research investigates the communication between the nervous and immune systems, focusing on how vagal sensory neurons detect and encode information about inflammatory mediators like cytokines. By using advanced techniques such as genetically encoded calcium indicators, the study aims to monitor the activity of these neurons in real-time as they respond to specific immune signals. This understanding could shed light on the mechanisms behind various inflammatory disorders and how the body maintains immune balance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing inflammatory disorders or conditions related to immune dysregulation.
Not a fit: Patients with non-inflammatory conditions or those not affected by immune system issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treating inflammatory disorders by improving our understanding of immune system regulation.
How similar studies have performed: Previous research has shown promising results in understanding neuro-immune communication, making this approach both relevant and potentially impactful.
Where this research is happening
Manhasset, United States
- Feinstein Institute for Medical Research — Manhasset, United States (Active)
Researchers
- Principal investigator: Chang, Eric Hau-Yun — Feinstein Institute for Medical Research
- Study coordinator: Chang, Eric Hau-Yun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.