How vaccines shape immune responses to COVID-19, flu, and dengue
Viral Immunity and VAccination (VIVA) Human Immunology Project Consortium (HIPC)
This project will look at how the immune systems of people getting COVID-19, seasonal flu, or dengue vaccines change over time using blood and tissue samples.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11370590 on NIH RePORTER |
What this research studies
You would be part of a group whose blood and other samples are collected before and after vaccination to see how immune cells and genes respond. The team will use advanced immune profiling and genomics to create detailed immune 'signatures' linked to vaccine protection for COVID-19, seasonal flu, and dengue. Samples come from existing cohorts and vaccine trials in the US and Argentina, and some lab experiments will use donated tonsil tissue exposed to vaccines. Results will be combined across projects to find patterns that might predict who responds best to different vaccines.
Who could benefit from this research
Good fit: Ideal candidates are people enrolled in participating cohorts or vaccine trials who are receiving COVID-19, seasonal influenza, or dengue vaccines and can provide blood or tissue samples.
Not a fit: People not receiving those vaccines, unable to travel to participating sites, or unable to give blood or tissue samples may not directly benefit from participating.
Why it matters
Potential benefit: If successful, this work could help predict who will be well protected by specific vaccines and guide improved vaccine design and vaccination strategies.
How similar studies have performed: Related immune-profiling studies have found signatures linked to responses for single vaccines, but combining COVID-19, flu, and dengue in one coordinated program is relatively new.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Fernandez-Sesma, Ana — Icahn School of Medicine at Mount Sinai
- Study coordinator: Fernandez-Sesma, Ana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.