How UVB radiation affects skin signaling through tiny particles
Official title: UVB radiation-generated microvesicle particles as effectors for photosensitivity
Funded at Wright State University · NIH-11017002 · Data updated 2026-11-12
This study is looking at how UVB rays from the sun affect your skin and send signals throughout your body, focusing on tiny particles released by skin cells that might carry important substances influencing your health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wright State University NIH-funded |
| Lab location | 1 site (Dayton, United States) |
| Project start | April 1, 2021 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $337,500 |
| NIH project number | 5R01ES031087-05 |
| Project ID | NIH-11017002 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who experience photosensitivity or related skin conditions affected by UVB radiation.
✕Less likely to help
Patients who do not have any sensitivity to UVB radiation or related skin conditions may not benefit from this research.
What this research studies
This research investigates how ultraviolet B (UVB) radiation impacts the skin and generates signals that affect the entire body. It focuses on small particles called microvesicle particles (MVP) that are released from skin cells in response to UVB exposure. By studying these MVPs, the research aims to understand their role in systemic signaling and how they may carry important bioactive lipids that influence various bodily functions. The approach includes using antioxidants and specific cell lines to explore the mechanisms behind these processes.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how UVB exposure affects overall health and potentially inform treatments for conditions related to photosensitivity.
How similar studies have gone: While the role of microvesicle particles in signaling is an emerging field, previous studies have shown promising results in understanding cellular responses to UVB radiation, suggesting potential for success in this area.
Where this research is happening
-
Wright State University
Dayton, United States Active
Researchers
- Principal investigator: Travers, Jeffrey B. — Wright State University
- Study coordinator: Travers, Jeffrey B.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.