How unique cells control the growth of developing intestinal stem cells
Official title: Regulation of developing intestinal stem cells by unique secretory cells
Funded at Clarkson University · NIH-10438109 · Data updated 2026-11-12
This study is looking at how special cells in the intestines help young stem cells grow and develop, using zebrafish to see these interactions clearly, which could help us learn more about how our own intestinal cells work.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clarkson University NIH-funded |
| Lab location | 1 site (Potsdam, United States) |
| Project start | June 21, 2022 |
| Project end | May 31, 2026 |
| Funding year | 2022 |
| Award (this year) | $429,897 |
| NIH project number | 1R15HD108689-01 |
| Project ID | NIH-10438109 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may be affected by intestinal disorders or cancers.
✕Less likely to help
Patients with non-intestinal related health issues or those under 21 years old may not receive benefits from this research.
What this research studies
This research investigates the role of unique secretory cells in regulating the growth and maturation of intestinal stem cells during their development. By studying zebrafish, which have transparent embryos, researchers can observe how these secretory cells interact with stem cells and influence their proliferation and maturation. The study aims to uncover novel signaling pathways and cellular interactions that are crucial for the proper development of the intestinal epithelium. Understanding these processes may provide insights into how intestinal stem cells function and develop in humans.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing intestinal health and treating related diseases, including cancers.
How similar studies have gone: While the specific approach of this research is novel, similar studies have shown promise in understanding stem cell regulation in other contexts.
Where this research is happening
-
Clarkson University
Potsdam, United States Active
Researchers
- Principal investigator: Wallace, Kenneth N — Clarkson University
- Study coordinator: Wallace, Kenneth N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.