How unexpected events can improve memory and learning
The role of novelty and surprise in aversive conditioning
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-11084277
This study is looking at how surprising and new experiences can help us remember things better, and it's for anyone interested in improving memory, especially those dealing with conditions like Alzheimer's or ADHD.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-11084277 on ClinicalTrials.gov |
What this research studies
This research investigates how novelty and surprise can enhance learning and memory processes. By examining the effects of unexpected events on memory rehearsal, the study aims to understand the underlying mechanisms that facilitate better memory retention. The approach involves both human participants and animal models to explore how these surprising experiences trigger the release of important neurotransmitters like norepinephrine and dopamine, which are crucial for memory formation. The findings could lead to new strategies for improving memory in various conditions, including Alzheimer's disease and ADHD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Alzheimer's disease, ADHD, or other conditions that affect memory and learning.
Not a fit: Patients with stable cognitive function and no memory-related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative methods for enhancing memory and learning in patients with cognitive impairments.
How similar studies have performed: Previous research has shown that novelty and surprise can positively impact memory, suggesting that this approach has potential for success.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WILTGEN, BRIAN J — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: WILTGEN, BRIAN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease