How unexpected events can improve memory and learning
Official title: The role of novelty and surprise in aversive conditioning
Funded at University of California at Davis · NIH-11084277 · Data updated 2026-11-12
This study is looking at how surprising and new experiences can help us remember things better, and it's for anyone interested in improving memory, especially those dealing with conditions like Alzheimer's or ADHD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $90,332 |
| NIH project number | 3R01NS129217-02S1 |
| Project ID | NIH-11084277 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with Alzheimer's disease, ADHD, or other conditions that affect memory and learning.
✕Less likely to help
Patients with stable cognitive function and no memory-related disorders may not benefit from this research.
What this research studies
This research investigates how novelty and surprise can enhance learning and memory processes. By examining the effects of unexpected events on memory rehearsal, the study aims to understand the underlying mechanisms that facilitate better memory retention. The approach involves both human participants and animal models to explore how these surprising experiences trigger the release of important neurotransmitters like norepinephrine and dopamine, which are crucial for memory formation. The findings could lead to new strategies for improving memory in various conditions, including Alzheimer's disease and ADHD.
Why it matters
Potential benefit: If successful, this research could lead to innovative methods for enhancing memory and learning in patients with cognitive impairments.
How similar studies have gone: Previous research has shown that novelty and surprise can positively impact memory, suggesting that this approach has potential for success.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Wiltgen, Brian J — University of California at Davis
- Study coordinator: Wiltgen, Brian J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.