How unexpected events can improve memory and learning
Official title: The role of novelty and surprise in aversive conditioning
Funded at University of California at Davis · NIH-10881909 · Data updated 2026-11-12
This study is looking at how surprising and new experiences can help us learn and remember better, and it might lead to new ways to support people with memory issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $567,184 |
| NIH project number | 5R01NS129217-02 |
| Project ID | NIH-10881909 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing memory issues related to conditions such as Alzheimer's disease or ADHD.
✕Less likely to help
Patients with stable cognitive function and no memory-related concerns may not receive any benefit from this research.
What this research studies
This research investigates how novelty and surprise can enhance learning and memory processes. It explores the mechanisms by which unexpected events trigger the release of important neurotransmitters, norepinephrine and dopamine, which are crucial for forming new memories. By examining both human and animal responses to surprising stimuli, the study aims to understand how these experiences can be harnessed to improve memory retention. Patients may benefit from insights that could lead to new therapeutic strategies for memory-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to innovative approaches for improving memory in patients with cognitive impairments.
How similar studies have gone: Previous research has shown that novelty and surprise can enhance memory, suggesting that this approach has potential for meaningful advancements.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Wiltgen, Brian J — University of California at Davis
- Study coordinator: Wiltgen, Brian J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.