How type 2 diabetes inflammation affects stroke recovery
Official title: Type 2 diabetes induced chronic inflammation on stroke outcome
Funded at Northern California Institute/res/edu · NIH-11238877 · Data updated 2026-11-12
This project is looking at whether inflammation caused by type 2 diabetes makes strokes more damaging and which immune proteins and white blood cells are responsible.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $591,470 |
| NIH project number | 5R01NS137082-02 |
| Project ID | NIH-11238877 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with type 2 diabetes who have had an ischemic stroke or are at high risk for stroke would be the most directly relevant group for future related clinical efforts.
✕Less likely to help
People without diabetes or those with hemorrhagic (bleeding) strokes are less likely to benefit from therapies aimed at diabetes-related complement-driven inflammation.
What this research studies
This work uses mouse models of type 2 diabetes to mimic how diabetes changes the brain before and after a stroke. Scientists measure immune activity in brain cells using single-cell RNA sequencing and live multiphoton imaging to watch blood flow and immune cells in tiny brain vessels. They focus on the complement system (proteins like C3 and C5) and on white blood cell and platelet behavior to see which signals drive worse injury. In the lab they will test whether blocking those complement signals reduces inflammation and improves recovery after stroke in diabetic mice.
Why it matters
Potential benefit: If successful, this work could point to immune targets that might lower brain damage and improve recovery after stroke in people with type 2 diabetes.
How similar studies have gone: Previous animal studies and human observational data link complement activation to worse ischemic brain injury and diabetes complications, but effective human treatments targeting complement remain unproven.
Where this research is happening
-
Northern California Institute/res/edu
San Francisco, United States Active
Researchers
- Principal investigator: Liu, Jialing — Northern California Institute/res/edu
- Study coordinator: Liu, Jialing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.