How type 2 diabetes inflammation affects stroke recovery
Type 2 diabetes induced chronic inflammation on stroke outcome
This project is looking at whether inflammation caused by type 2 diabetes makes strokes more damaging and which immune proteins and white blood cells are responsible.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11238877 on NIH RePORTER |
What this research studies
This work uses mouse models of type 2 diabetes to mimic how diabetes changes the brain before and after a stroke. Scientists measure immune activity in brain cells using single-cell RNA sequencing and live multiphoton imaging to watch blood flow and immune cells in tiny brain vessels. They focus on the complement system (proteins like C3 and C5) and on white blood cell and platelet behavior to see which signals drive worse injury. In the lab they will test whether blocking those complement signals reduces inflammation and improves recovery after stroke in diabetic mice.
Who could benefit from this research
Good fit: Adults with type 2 diabetes who have had an ischemic stroke or are at high risk for stroke would be the most directly relevant group for future related clinical efforts.
Not a fit: People without diabetes or those with hemorrhagic (bleeding) strokes are less likely to benefit from therapies aimed at diabetes-related complement-driven inflammation.
Why it matters
Potential benefit: If successful, this work could point to immune targets that might lower brain damage and improve recovery after stroke in people with type 2 diabetes.
How similar studies have performed: Previous animal studies and human observational data link complement activation to worse ischemic brain injury and diabetes complications, but effective human treatments targeting complement remain unproven.
Where this research is happening
San Francisco, United States
- Northern California Institute/res/edu — San Francisco, United States (Active)
Researchers
- Principal investigator: Liu, Jialing — Northern California Institute/res/edu
- Study coordinator: Liu, Jialing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.