How type 2 diabetes affects stroke outcomes and inflammation
Type 2 diabetes induced chronic inflammation on stroke outcome
This study is looking at how type 2 diabetes affects recovery after a stroke by exploring how inflammation and blood flow issues in the brain might make things worse, with the hope of finding new ways to help people with diabetes recover better after a stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11051042 on NIH RePORTER |
What this research studies
This research investigates the impact of type 2 diabetes on stroke outcomes, focusing on the role of chronic inflammation and complement activation in worsening these outcomes. By using advanced techniques like single cell transcriptomics and multiphoton imaging, the study aims to understand how diabetes-related changes in the brain contribute to stroke severity. The research will explore the mechanisms behind poor blood flow and increased inflammation in the brains of diabetic mice, which could provide insights into potential therapeutic targets for improving stroke recovery in diabetic patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with type 2 diabetes who have experienced a stroke or are at high risk of stroke.
Not a fit: Patients without type 2 diabetes or those who have not experienced a stroke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for stroke patients with type 2 diabetes, potentially enhancing recovery and reducing complications.
How similar studies have performed: Previous research has shown that understanding the role of inflammation in stroke outcomes can lead to significant advancements in treatment, suggesting that this approach has the potential for success.
Where this research is happening
San Francisco, United States
- Northern California Institute/res/edu — San Francisco, United States (Active)
Researchers
- Principal investigator: Liu, Jialing — Northern California Institute/res/edu
- Study coordinator: Liu, Jialing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.