How type 2 diabetes affects stroke outcomes and inflammation
Official title: Type 2 diabetes induced chronic inflammation on stroke outcome
Funded at Northern California Institute/res/edu · NIH-11051042 · Data updated 2026-11-12
This study is looking at how type 2 diabetes affects recovery after a stroke by exploring how inflammation and blood flow issues in the brain might make things worse, with the hope of finding new ways to help people with diabetes recover better after a stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $604,795 |
| NIH project number | 1R01NS137082-01A1 |
| Project ID | NIH-11051042 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with type 2 diabetes who have experienced a stroke or are at high risk of stroke.
✕Less likely to help
Patients without type 2 diabetes or those who have not experienced a stroke may not benefit from this research.
What this research studies
This research investigates the impact of type 2 diabetes on stroke outcomes, focusing on the role of chronic inflammation and complement activation in worsening these outcomes. By using advanced techniques like single cell transcriptomics and multiphoton imaging, the study aims to understand how diabetes-related changes in the brain contribute to stroke severity. The research will explore the mechanisms behind poor blood flow and increased inflammation in the brains of diabetic mice, which could provide insights into potential therapeutic targets for improving stroke recovery in diabetic patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for stroke patients with type 2 diabetes, potentially enhancing recovery and reducing complications.
How similar studies have gone: Previous research has shown that understanding the role of inflammation in stroke outcomes can lead to significant advancements in treatment, suggesting that this approach has the potential for success.
Where this research is happening
-
Northern California Institute/res/edu
San Francisco, United States Active
Researchers
- Principal investigator: Liu, Jialing — Northern California Institute/res/edu
- Study coordinator: Liu, Jialing
Related research
Other NIH-funded projects on the same topics.
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How type 2 diabetes inflammation affects stroke recovery
This project is looking at whether inflammation caused by type 2 diabetes makes strokes more damaging and which immune proteins and white blood cells are responsible.
-
Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)
A new U01 grant from a university research team aims to understand why Type 2 diabetes differs so much between people and how to tailor prevention and treatment.
-
Michigan Diabetes Project: A Peer-Led Self-Management Program for Adults with Type 2 Diabetes
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Alzheimer’s and dementia risk in people with prediabetes or type 2 diabetes
This grant aims to understand why some older adults with prediabetes or type 2 diabetes develop memory problems or dementia.
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Personalized use of newer diabetes medicines for Type 2 diabetes
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-
Alzheimer’s and related dementia in older adults with prediabetes or type 2 diabetes
This grant aims to understand why cognitive problems occur in people 65 and older who have prediabetes or type 2 diabetes, using data from a long-running diabetes study to identify what drives memory and thinking decline.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.