How two common types of stomach cancer begin
Initiation of Diffuse and Intestinal Non-Cardia Gastric Cancer
Researchers will use engineered mouse models and advanced tissue mapping to learn how genetic changes and H. pylori infection lead to the two main forms of stomach cancer, aiming to help people at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11187015 on NIH RePORTER |
What this research studies
This project models the early genetic hits (like CDH1 and p53 loss) and environmental exposures (Helicobacter pylori and dietary nitrates) that drive the two main types of stomach cancer using engineered mouse models. Scientists will profile individual cells with combined gene-expression and chromatin-accessibility tools and then map those cell types back into their normal spatial location in the stomach using spatial transcriptomics. By linking genetics, environment, and precise cell identity, the team aims to define the cells of origin and the molecular steps that lead to cancer. That information could point to early detection markers or prevention targets.
Who could benefit from this research
Good fit: People who might be most relevant include those with hereditary CDH1 mutations, chronic H. pylori infection, or a strong family history of stomach cancer who are interested in contributing samples or participating in future related studies.
Not a fit: Patients needing immediate treatment for existing stomach cancer are unlikely to receive direct clinical benefit from this basic-science project.
Why it matters
Potential benefit: If successful, this work could identify early markers or targets that help prevent or detect diffuse and intestinal stomach cancers sooner.
How similar studies have performed: Related single-cell and spatial profiling approaches have helped reveal cell types and origins in other cancers, but combining these methods specifically for diffuse and intestinal gastric cancer is relatively new.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Ryeom, Sandra — Columbia University Health Sciences
- Study coordinator: Ryeom, Sandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.