How tumor cell metabolism is influenced by cytoskeletal regulation in pancreatic cancer
Official title: Intersection of cytoskeletal regulation with tumor cell metabolism
Funded at Mayo Clinic Rochester · NIH-10996553 · Data updated 2026-11-12
This study is looking at how a specific gene called Vav1 influences the growth and spread of pancreatic cancer, with the hope of finding new ways to help patients live longer and healthier lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $429,079 |
| NIH project number | 1R01CA294653-01 |
| Project ID | NIH-10996553 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with pancreatic cancer, particularly those with aggressive forms of the disease.
✕Less likely to help
Patients with non-cancerous conditions or those with early-stage pancreatic cancer may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms that drive tumor progression and metastasis in pancreatic cancer, particularly focusing on the role of the proto-oncogene Vav1. By examining how Vav1 affects glutamine metabolism and its relationship with actin dynamics, the study aims to uncover new therapeutic strategies that could enhance patient survival. The approach combines cellular models and biochemical analysis to explore how these interactions contribute to cancer cell invasion and proliferation.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that improve survival rates for patients with pancreatic cancer.
How similar studies have gone: Previous research has shown promising results in targeting metabolic pathways in cancer, suggesting that this approach could yield significant insights.
Where this research is happening
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Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Razidlo, Gina Lynn — Mayo Clinic Rochester
- Study coordinator: Razidlo, Gina Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.