How tumor cell metabolism affects immune response in triple-negative breast cancer
Effect of tumor cell glutamine metabolism on anti-tumor immunity in TNBC
This study is looking at how cancer cells and immune cells use a nutrient called glutamine in triple-negative breast cancer, and it hopes to find ways to boost the immune system's ability to fight the cancer by blocking how tumor cells use glutamine.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10885946 on NIH RePORTER |
What this research studies
This research investigates the role of glutamine metabolism in triple-negative breast cancer (TNBC) and its impact on anti-tumor immunity. The study focuses on how tumor cells and immune cells compete for glutamine, a vital nutrient, and how this competition influences the effectiveness of immune responses against tumors. By examining the effects of inhibiting glutamine metabolism in tumor cells, the research aims to enhance the activity of cytotoxic CD8 T lymphocytes, which are crucial for fighting cancer. The findings could lead to new therapeutic strategies that improve immune responses in patients with TNBC.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with triple-negative breast cancer who may benefit from novel immunotherapy approaches.
Not a fit: Patients with non-triple-negative breast cancer subtypes are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance the immune system's ability to fight triple-negative breast cancer.
How similar studies have performed: Other research has shown promising results in targeting metabolic pathways in cancer, suggesting that this approach may yield significant insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Chen, Jin — Vanderbilt University Medical Center
- Study coordinator: Chen, Jin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.