How tumor-associated macrophages affect immune responses in cancer
Regulation of tumor-infiltrating T cells by macrophages
This study is looking at how certain immune cells called tumor-associated macrophages (TAMs) affect the body's ability to fight cancer, and it aims to find ways to help another type of immune cell, CD8 T cells, work better against tumors, which could lead to new treatments for cancer patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11097150 on NIH RePORTER |
What this research studies
This research investigates the role of tumor-associated macrophages (TAMs) in regulating immune responses within tumors. It aims to understand how these macrophages, which often promote tumor growth and immune evasion, can be manipulated to enhance the function of CD8 T cells, a type of immune cell crucial for attacking tumors. The study will explore the mechanisms by which TAMs express certain proteins that lead to T cell dysfunction and will develop strategies to improve T cell infiltration and activity in tumors. By focusing on the tumor microenvironment, the research seeks to uncover new therapeutic approaches for cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers that exhibit significant tumor-associated macrophage activity and immune evasion.
Not a fit: Patients with cancers that do not involve significant interactions between tumor-associated macrophages and immune cells may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative cancer therapies that enhance the immune system's ability to fight tumors.
How similar studies have performed: Other research has shown promising results in targeting tumor-associated macrophages to improve anti-tumor immunity, indicating that this approach has potential for success.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Huang, Xiaopei — Ohio State University
- Study coordinator: Huang, Xiaopei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.