How tuberculosis changes the hidden HIV reservoir
Official title: Impact of TB coinfection on HIV reservoir
Funded at Weill Medical Coll of Cornell Univ · NIH-11459107 · Data updated 2026-11-12
This project looks at whether active tuberculosis changes the amount and types of hidden HIV in people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 11, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $154,436 |
| NIH project number | 3R01AI176943-03S1 |
| Project ID | NIH-11459107 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people newly diagnosed with HIV, with or without active tuberculosis, who can provide blood samples and clinical history.
✕Less likely to help
People without HIV or those far outside the study area who cannot provide samples or attend study visits are unlikely to benefit or participate.
What this research studies
If you join, researchers will enroll people newly diagnosed with HIV who do or do not have active TB and collect blood and immune cells. They will measure how much hidden (latent) HIV is present in CD4 immune cells and which immune cell types carry HIV. The team will compare T cell receptor diversity and the genetic intactness of HIV proviruses between people with and without TB. Findings will help explain why people with HIV and TB have worse long-term outcomes and point toward ways to target the hidden HIV reservoir.
Why it matters
Potential benefit: If successful, this work could reveal targets to reduce or eliminate the hidden HIV reservoir and improve cure strategies for people with HIV who have had TB.
How similar studies have gone: Epidemiologic studies show worse outcomes for HIV-TB coinfection, but detailed molecular analysis of the HIV reservoir in this setting is relatively new and not yet well established.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Dupnik, Kathryn M — Weill Medical Coll of Cornell Univ
- Study coordinator: Dupnik, Kathryn M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.