How tuberculosis changes hidden HIV in the body
Impact of TB coinfection on HIV reservoir
Researchers will compare the hidden HIV reservoir in people with HIV who do and do not have tuberculosis to learn how TB might change where HIV hides.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11223325 on NIH RePORTER |
What this research studies
If you join, researchers will enroll people newly diagnosed with HIV, some who also have active TB and some who do not. They will collect blood and immune cells and use molecular tests to measure intact HIV provirus within CD4 T cells and to map which immune cell types carry HIV. The team will also compare the diversity of T cell receptors to see if TB shifts which immune cells harbor HIV. The goal is to find biological changes linked to TB that could be targeted to lower or remove the hidden HIV reservoir.
Who could benefit from this research
Good fit: Adults newly diagnosed with HIV who can come to GHESKIO Centers in Port-au-Prince, Haiti, including those with and without active TB, are the intended participants.
Not a fit: People without HIV, those not able to travel to the study site, or those whose HIV is long-established and not part of the enrollment criteria may not receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could point to ways to reduce or eliminate the hidden HIV reservoir and improve long-term outcomes for people living with HIV and TB.
How similar studies have performed: Using molecular assays to measure HIV reservoirs is an established approach in HIV research, but comparing reservoir features between TB-coinfected and non-coinfected people is a newer, less-tested application.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Dupnik, Kathryn M — Weill Medical Coll of Cornell Univ
- Study coordinator: Dupnik, Kathryn M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.