How tuberculosis bacteria manage sugar metabolism to resist drugs
Official title: Interplay of M. tuberculosis trehalose metabolism and its pathogenesis and drug resistance
Funded at University of Southern California · NIH-11041029 · Data updated 2026-11-12
This study is looking at how the tuberculosis bacteria change the way they use sugar to survive against antibiotics, which could help us find new ways to treat drug-resistant TB.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | March 16, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $645,686 |
| NIH project number | 5R01AI168088-03 |
| Project ID | NIH-11041029 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with drug-resistant tuberculosis or those at high risk of developing drug resistance.
✕Less likely to help
Patients with drug-sensitive tuberculosis or those without a history of TB infection may not benefit from this research.
What this research studies
This research investigates how Mycobacterium tuberculosis, the bacteria causing tuberculosis (TB), alters its sugar metabolism to survive against antibiotic treatments. By focusing on the role of trehalose, a sugar that the bacteria use, the study aims to understand the mechanisms that allow TB to develop drug resistance. The researchers will utilize advanced metabolomics techniques to analyze how these bacteria adapt their metabolic processes, which could lead to new strategies for treating drug-resistant TB. This work is crucial as it addresses a significant public health challenge posed by drug-resistant TB strains.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for drug-resistant tuberculosis, potentially reducing treatment costs and improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding bacterial metabolism and drug resistance, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Eoh, Hyungjin — University of Southern California
- Study coordinator: Eoh, Hyungjin
Related research
Other NIH-funded projects on the same topics.
-
Coronary disease and immune activation in people with HIV and tuberculosis coinfection
This research looks at how having HIV and latent tuberculosis together might raise the risk of heart disease, and what immune changes are involved.
-
Pulmonary rehabilitation to reduce breathing problems after tuberculosis
A program of guided exercise and breathing training to help adults who have recovered from TB breathe better and feel healthier.
-
Pulmonary rehab to reduce breathing troubles after TB
A program of pulmonary rehabilitation is being studied to help adults who have completed TB treatment avoid ongoing lung problems and improve daily breathing.
-
Air pollution and tuberculosis spread in Kampala, Uganda
This project looks at whether dirty air from PM2.5 particles makes tuberculosis more likely to spread within urban slum households in Kampala, Uganda.
-
Air pollution and TB spread in Ugandan urban slums
This project explores whether exposure to air pollution makes tuberculosis more likely to spread within households in a crowded Ugandan slum.
-
Air pollution and TB transmission in Kampala’s urban slums
This project looks at whether air pollution from PM2.5 makes tuberculosis spread more easily from infected people to their neighbors in urban slums of Kampala, Uganda.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.