How tuberculosis bacteria manage sugar metabolism to resist drugs
Interplay of M. tuberculosis trehalose metabolism and its pathogenesis and drug resistance
This study is looking at how the tuberculosis bacteria change the way they use sugar to survive against antibiotics, which could help us find new ways to treat drug-resistant TB.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11041029 on NIH RePORTER |
What this research studies
This research investigates how Mycobacterium tuberculosis, the bacteria causing tuberculosis (TB), alters its sugar metabolism to survive against antibiotic treatments. By focusing on the role of trehalose, a sugar that the bacteria use, the study aims to understand the mechanisms that allow TB to develop drug resistance. The researchers will utilize advanced metabolomics techniques to analyze how these bacteria adapt their metabolic processes, which could lead to new strategies for treating drug-resistant TB. This work is crucial as it addresses a significant public health challenge posed by drug-resistant TB strains.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with drug-resistant tuberculosis or those at high risk of developing drug resistance.
Not a fit: Patients with drug-sensitive tuberculosis or those without a history of TB infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for drug-resistant tuberculosis, potentially reducing treatment costs and improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding bacterial metabolism and drug resistance, indicating that this approach could yield valuable insights.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Eoh, Hyungjin — University of Southern California
- Study coordinator: Eoh, Hyungjin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.