How tuberculosis affects immunity in people with HIV
Official title: Mycobacterium tuberculosis disease effect on HIV-1 immunity, evolution, and persistence
Funded at Boston Medical Center · NIH-11211498 · Data updated 2026-11-12
This study is looking at how tuberculosis affects the immune system in people with HIV, focusing on how it changes their ability to fight HIV and whether it leads to tougher strains of the virus.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 11, 2025 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $711,993 |
| NIH project number | 1R56AI186777-01A1 |
| Project ID | NIH-11211498 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who also have active tuberculosis disease.
✕Less likely to help
Patients who are HIV-negative or do not have tuberculosis may not benefit from this research.
What this research studies
This research investigates the impact of Mycobacterium tuberculosis (Mtb) on the immune response in individuals living with HIV. It aims to understand how Mtb disease influences the development of HIV-1 neutralizing antibodies and the characteristics of the virus in these patients. By comparing individuals with active Mtb disease to those without, the study will explore changes in HIV-1 pathogenesis and the potential emergence of resistant strains. The research employs advanced models to assess immune cell functionality and antibody responses.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for HIV-infected individuals co-infected with tuberculosis.
How similar studies have gone: Previous research has shown that co-infections can significantly alter immune responses, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Boston Medical Center
Boston, United States Active
Researchers
- Principal investigator: Sagar, Manish — Boston Medical Center
- Study coordinator: Sagar, Manish
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.