How tuberculosis affects immunity in people with HIV
Mycobacterium tuberculosis disease effect on HIV-1 immunity, evolution, and persistence
This study is looking at how tuberculosis affects the immune system in people with HIV, focusing on how it changes their ability to fight HIV and whether it leads to tougher strains of the virus.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11211498 on NIH RePORTER |
What this research studies
This research investigates the impact of Mycobacterium tuberculosis (Mtb) on the immune response in individuals living with HIV. It aims to understand how Mtb disease influences the development of HIV-1 neutralizing antibodies and the characteristics of the virus in these patients. By comparing individuals with active Mtb disease to those without, the study will explore changes in HIV-1 pathogenesis and the potential emergence of resistant strains. The research employs advanced models to assess immune cell functionality and antibody responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who also have active tuberculosis disease.
Not a fit: Patients who are HIV-negative or do not have tuberculosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for HIV-infected individuals co-infected with tuberculosis.
How similar studies have performed: Previous research has shown that co-infections can significantly alter immune responses, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Boston Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Sagar, Manish — Boston Medical Center
- Study coordinator: Sagar, Manish
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.