How tuberculosis affects HIV infection in patients
Official title: Impact of TB coinfection on HIV reservoir
Funded at Weill Medical Coll of Cornell Univ · NIH-10999428 · Data updated 2026-11-12
This study is looking at how tuberculosis (TB) affects the HIV virus in people living with HIV, to help find better treatments for those who have both conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 11, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $706,315 |
| NIH project number | 5R01AI176943-02 |
| Project ID | NIH-10999428 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who may or may not have a concurrent diagnosis of tuberculosis.
✕Less likely to help
Patients who do not have HIV or tuberculosis are unlikely to benefit from this research.
What this research studies
This research investigates the impact of tuberculosis (TB) on the HIV reservoir in people living with HIV (PLHIV). It aims to understand the mechanisms that lead to worse health outcomes for those with both HIV and TB, focusing on how TB may alter the distribution of HIV within immune cells. By enrolling participants with HIV, with or without TB, the study will analyze differences in the HIV proviral reservoir, which is crucial for developing strategies to eradicate HIV. The findings could lead to targeted treatments that improve health outcomes for PLHIV who also have TB.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for eradicating HIV in patients who are also infected with tuberculosis.
How similar studies have gone: Previous research has shown significant health disparities in patients with HIV and TB co-infection, indicating that this area of investigation is critical and may lead to impactful findings.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Dupnik, Kathryn M — Weill Medical Coll of Cornell Univ
- Study coordinator: Dupnik, Kathryn M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.