How TRPV2 and TRPV5 ion channels control calcium and cell activity
Structure and Function of TRPV channels
Researchers are mapping the shapes and actions of two cell ion channels, TRPV2 and TRPV5, to learn how they control calcium and affect nerves, immunity, the heart, kidneys, and cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11260166 on NIH RePORTER |
What this research studies
The team uses high-resolution methods such as cryo-electron microscopy along with biochemical and cellular experiments to visualize TRPV2 and TRPV5 at the atomic level. They will determine how these channels open and close and how natural or drug-like molecules change their activity. The project links molecular findings to TRPV2 roles in neuronal development and immunity and to TRPV5's role in kidney calcium handling using cell-based and related model systems. Results are meant to connect basic channel mechanics to how these proteins influence tissues and disease processes.
Who could benefit from this research
Good fit: People with conditions tied to TRPV biology—such as certain cancers, kidney calcium imbalance, or related neurological or immune disorders—would be most likely to follow this work or be candidates for future trials.
Not a fit: Patients seeking immediate treatment changes are unlikely to benefit because this is basic laboratory research focused on molecular mechanisms rather than a clinical treatment trial.
Why it matters
Potential benefit: If successful, this work could point to new drug targets for cancers, kidney calcium disorders, and some neurological or immune conditions linked to TRPV channels.
How similar studies have performed: High-resolution structural studies have revealed mechanisms for other ion channels and prior work has advanced TRPV structures, but turning those insights into therapies remains at an early stage.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Moiseenkova-Bell, Vera — University of Pennsylvania
- Study coordinator: Moiseenkova-Bell, Vera
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.