How TRPC6 channels affect the healing of blood vessels
Official title: Endothelial Healing is Inhibited by Activation of TRPC6 Channels
Funded at Louis Stokes Cleveland VA Medical Center · NIH-11098501 · Data updated 2026-11-12
This study is looking at how certain channels in blood vessel cells can affect their ability to heal after injuries, especially in older adults and veterans, with the goal of finding new ways to help these cells recover better and prevent problems after procedures.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louis Stokes Cleveland VA Medical Center NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| NIH project number | 5I01BX005823-04 |
| Project ID | NIH-11098501 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those aged 65 and above, who are at risk for cardiovascular diseases.
✕Less likely to help
Patients under the age of 65 or those without cardiovascular disease may not receive benefit from this research.
What this research studies
This research investigates the role of TRPC6 channels in the healing process of endothelial cells, which line blood vessels. It focuses on how the activation of these channels can inhibit the migration of endothelial cells necessary for repairing injuries in blood vessels, particularly in older adults and veterans. By understanding this mechanism, the research aims to identify potential therapeutic targets to enhance endothelial healing and reduce complications such as restenosis after vascular procedures. The study employs both in vitro and in vivo methodologies to explore these cellular processes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cardiovascular disease, particularly in enhancing the healing of blood vessels and reducing the risk of complications after procedures.
How similar studies have gone: Previous research has shown that targeting cellular mechanisms involved in endothelial healing can lead to significant improvements in vascular health, suggesting that this approach may yield promising results.
Where this research is happening
-
Louis Stokes Cleveland VA Medical Center
Cleveland, United States Active
Researchers
- Principal investigator: Rosenbaum, Michael Aaric — Louis Stokes Cleveland VA Medical Center
- Study coordinator: Rosenbaum, Michael Aaric
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.