How trophoblast cells help establish a successful pregnancy
Trophoblast-Guided Uterine Transformation in the Establishment of Pregnancy
['FUNDING_R01'] · UNIVERSITY OF KANSAS MEDICAL CENTER · NIH-11032820
This study is looking at how certain cells from the embryo help create a welcoming environment in the uterus for a healthy pregnancy, and it aims to learn more about a specific protein that plays a key role in this process, which could help us understand why some pregnancies don't go as planned.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS MEDICAL CENTER (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-11032820 on ClinicalTrials.gov |
What this research studies
This research investigates the role of trophoblast cells, which are derived from the embryo, in transforming the uterine environment to support a successful pregnancy. By studying both rat and human models, the research aims to understand how these cells infiltrate the uterus and interact with various maternal cells, including immune and endothelial cells. The project focuses on a specific protein, PLAC1, that regulates the development of invasive trophoblast cells, which are crucial for proper placentation. The findings could provide insights into the causes of early pregnancy loss and related complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing early pregnancy complications or those at risk for placental-related disorders.
Not a fit: Patients who are not pregnant or those with unrelated reproductive health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of conditions that cause early pregnancy loss and placental dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding trophoblast cell functions, indicating that this approach has potential for significant advancements in reproductive health.
Where this research is happening
KANSAS CITY, UNITED STATES
- UNIVERSITY OF KANSAS MEDICAL CENTER — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SOARES, MICHAEL J — UNIVERSITY OF KANSAS MEDICAL CENTER
- Study coordinator: SOARES, MICHAEL J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.