How tRNA localization affects heart health and growth
Official title: Microtubule-mediated tRNA localization in cardiac homeostasis and hypertrophy
Funded at University of Pennsylvania · NIH-10999392 · Data updated 2026-11-12
This study is looking at how the location of a special molecule called transfer RNA in heart cells affects how those cells grow and handle stress, with the goal of finding new ways to treat heart problems like heart failure.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 7, 2023 |
| Project end | August 6, 2025 |
| Funding year | 2024 |
| Award (this year) | $74,284 |
| NIH project number | 5F32HL170583-02 |
| Project ID | NIH-10999392 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with cardiovascular diseases or those at risk of developing heart conditions due to factors like high blood pressure or obesity.
✕Less likely to help
Patients with non-cardiovascular related health issues or those without risk factors for heart disease may not benefit from this research.
What this research studies
This research investigates how the localization of transfer RNA (tRNA) in heart cells influences their growth and adaptation to stress. It focuses on understanding the mechanisms behind both healthy and unhealthy heart muscle growth, particularly in response to factors like high blood pressure and weight gain. By examining the role of tRNA in protein synthesis, the study aims to uncover new insights into cardiac remodeling, which could lead to innovative therapies for heart failure. Patients may benefit from advancements in treatment options that target the underlying causes of heart disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and prevent heart failure.
How similar studies have gone: While the specific focus on tRNA localization in cardiac health is relatively novel, there has been success in related research exploring the role of RNA in heart disease.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Petrosino, Jennifer Morgan — University of Pennsylvania
- Study coordinator: Petrosino, Jennifer Morgan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.