How TRIM proteins shape norovirus infection and which cells the virus can infect
The Role of Trim Proteins in Regulating Norovirus Replication and Tropism
This research looks at how TRIM proteins change norovirus growth and which cells the virus can infect to help people who get norovirus-related diarrhea.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11321742 on NIH RePORTER |
What this research studies
Researchers will use a mouse norovirus model and lab-grown cells to study two TRIM proteins (TRIM7 and TRIM47) that may block or permit viral replication. They will compare different norovirus strains to see which tissues and cell types each strain infects and how TRIM proteins influence that range. The team will apply genetic and molecular tools to find how TRIM proteins tag viral or host factors and limit infection. These lab-based findings could point to new ways to prevent or treat norovirus infections in people.
Who could benefit from this research
Good fit: People who get norovirus or who experience frequent or severe bouts of infectious diarrhea would be most relevant to benefit from future therapies informed by this work.
Not a fit: Patients whose diarrhea is due to non-infectious causes or unrelated medical conditions are unlikely to receive direct benefit from this basic laboratory research.
Why it matters
Potential benefit: If successful, this work could reveal new targets to stop norovirus replication and reduce diarrhea caused by these infections.
How similar studies have performed: Prior lab studies identified a universal murine norovirus receptor and initial TRIM restriction factors, but applying these findings to human noroviruses is still early and largely unproven.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Orchard, Robert C. — Ut Southwestern Medical Center
- Study coordinator: Orchard, Robert C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.