How transposable elements affect gene regulation and immunity
Transposon-mediated rewiring of gene regulatory networks
This study is looking at how certain genetic pieces called transposable elements affect how our genes respond to signals, especially in the immune system, to help us understand differences in health and disease among people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project ID | NIH-11096242 on NIH RePORTER |
What this research studies
This research investigates the role of transposable elements (TEs) in gene regulatory networks, which are crucial for how genes respond to various signals. By using advanced bioinformatics and experimental techniques, the team aims to understand how TEs influence immune responses and contribute to variations in gene regulation among individuals. The research will involve characterizing TE-derived gene expressions across different species and exploring their potential roles in health and disease. Patients may benefit from insights gained about immune function and disease susceptibility related to these genetic elements.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases or those interested in genetic factors influencing immune function.
Not a fit: Patients without autoimmune conditions or those not interested in genetic research may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses and understanding autoimmune conditions.
How similar studies have performed: Previous research has shown that transposable elements can significantly impact gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
Boulder, UNITED STATES
- University of Colorado — Boulder, United States (Active)
Researchers
- Principal investigator: Chuong, Edward Bo-Yi — University of Colorado
- Study coordinator: Chuong, Edward Bo-Yi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.