How transfused red blood cells last in people with sickle cell disease
Donor Red Blood Cell Survival in Recipients with Sickle Cell Disease
This project looks at which donor blood traits and patient factors make transfused red blood cells last longer in people with sickle cell disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11107474 on NIH RePORTER |
What this research studies
You would be followed after a red blood cell transfusion to see how long the donor cells remain in your bloodstream and why they disappear. Researchers will compare donor blood with common traits such as G6PD deficiency or alpha-thalassemia trait to donor blood without those traits. They will also look at recipient factors like past antibody responses and how the spleen and liver clear transfused cells. Blood samples and clinical follow-up will be used to measure cell survival and study the biological mechanisms behind faster clearance.
Who could benefit from this research
Good fit: People with sickle cell disease who are receiving or likely to receive red blood cell transfusions, including children and adults, would be ideal candidates.
Not a fit: People without sickle cell disease or those who do not need red blood cell transfusions are unlikely to get direct benefit from this research.
Why it matters
Potential benefit: If successful, this work could help doctors pick donor blood and manage transfusions so they last longer and protect people with sickle cell disease better.
How similar studies have performed: Prior studies and the investigators' preliminary data suggest donor traits can affect transfused red cell survival, but more work is needed to confirm and apply these findings clinically.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Yee, Marianne Elaine Mcpherson — Emory University
- Study coordinator: Yee, Marianne Elaine Mcpherson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.