How transcription factors work together to control gene activity based on the circadian clock
Cooperation between transcription factors and its role in the regulation of rhythmic enhancer activity by the circadian clock
This study is looking at how two important proteins, CLOCK and BMAL1, work together to control the timing of gene activity in our bodies, which is influenced by our internal body clock, and it aims to help us understand how changes in our environment can affect these natural rhythms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project ID | NIH-11084305 on NIH RePORTER |
What this research studies
This research investigates the interaction between transcription factors, specifically CLOCK and BMAL1, and their role in regulating gene expression in a rhythmic manner influenced by the circadian clock. By utilizing advanced techniques like chromatin immunoprecipitation coupled with sequencing, the study aims to uncover how these factors cooperate to bind DNA and manage the activity of regulatory elements. The goal is to better understand the mechanisms behind rhythmic gene expression and how environmental changes can reprogram these rhythms. This knowledge could lead to insights into various biological processes and conditions affected by circadian rhythms.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with conditions related to circadian rhythm disruptions, such as insomnia or metabolic syndrome.
Not a fit: Patients with conditions unrelated to circadian rhythms or transcription factor activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of circadian biology, potentially leading to new treatments for conditions influenced by circadian rhythms, such as sleep disorders and metabolic diseases.
How similar studies have performed: Previous research has shown promising results in understanding transcription factor interactions and circadian regulation, suggesting that this approach has the potential for significant advancements.
Where this research is happening
College Station, United States
- Texas A&m University — College Station, United States (Active)
Researchers
- Principal investigator: Menet, Jerome — Texas A&m University
- Study coordinator: Menet, Jerome
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.