How Toxoplasma gondii affects immune cell balance
Impact of Toxoplasma gondii on Treg homeostasis
This study looks at how the Toxoplasma gondii parasite affects a type of immune cell called regulatory T cells, focusing on what happens to these cells during and after an infection, to help us understand how our immune system works and find new ways to treat related health issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10901125 on NIH RePORTER |
What this research studies
This research investigates how the parasite Toxoplasma gondii impacts the population of regulatory T cells (Tregs) in the immune system. It focuses on understanding the collapse of Treg cells during acute infection and how these cells rebuild over time. The study aims to identify the cytokines involved in Treg repopulation and whether chronic inflammation alters Treg characteristics. By examining these processes, the research seeks to provide insights into immune responses and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic infections or immune system disorders that may be influenced by Treg dynamics.
Not a fit: Patients without chronic infections or those whose immune system function is not affected by Toxoplasma gondii may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to immune system dysfunction.
How similar studies have performed: Previous research has shown that understanding Treg dynamics in various infections can lead to significant advancements in immunology, suggesting this approach has potential for success.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Lanzar, Zachary R — University of Pennsylvania
- Study coordinator: Lanzar, Zachary R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.