How Toxoplasma affects immune responses in different types of macrophages
Toxoplasma effector-mediated modulation of innate immune pathways in non-murine macrophages
['FUNDING_OTHER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10890885
This study looks at how the Toxoplasma gondii parasite affects immune cells in humans and rats, aiming to understand why some people get really sick while others don’t, which could help improve treatments for those with weakened immune systems, like people with AIDS.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10890885 on ClinicalTrials.gov |
What this research studies
This research investigates how the Toxoplasma gondii parasite interacts with macrophages, a type of immune cell, particularly focusing on non-murine hosts like humans and rats. The study aims to understand the specific mechanisms by which Toxoplasma modulates immune responses through secreted proteins called effectors. By examining these interactions, the research seeks to uncover why some hosts experience severe disease while others do not. This could lead to insights into improving immune responses in vulnerable populations, such as those with AIDS.
Who could benefit from this research
Good fit: Ideal candidates for this research are immunocompromised individuals, particularly those with AIDS, as well as fetuses at risk of infection.
Not a fit: Patients who are not immunocompromised or do not have a history of Toxoplasma infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments and preventive strategies for immunocompromised patients affected by Toxoplasma.
How similar studies have performed: Previous research has shown success in understanding host-pathogen interactions in murine models, but this specific focus on non-murine macrophages is relatively novel.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, YIFAN — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: WANG, YIFAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome