How toxic metals affect Alzheimer's disease in aging mice
Impact of Toxic Metal Exposures in Novel Genetic Mouse Models of Late-Onset Alzheimer's Disease
This study is looking at how long-term exposure to harmful metals like lead and arsenic might affect the risk of developing late-onset Alzheimer's disease, using special mouse models to understand the connection better, which could help people learn more about how their environment impacts their brain health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10901030 on NIH RePORTER |
What this research studies
This research investigates the impact of chronic exposure to toxic metals like lead, cadmium, and arsenic on the development of late-onset Alzheimer's disease (LOAD) using innovative mouse models. By examining the interactions between genetic factors and environmental exposures, the study aims to uncover the molecular mechanisms that contribute to the risk of developing LOAD. The findings could help identify at-risk populations and inform strategies for prevention and intervention. Patients may benefit from insights into how environmental factors influence their health outcomes related to Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include older adults who may have been exposed to toxic metals and are at risk for Alzheimer's disease.
Not a fit: Patients who are not at risk for Alzheimer's disease or have no history of exposure to toxic metals may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for Alzheimer's disease linked to environmental toxicants.
How similar studies have performed: Previous research has shown that environmental factors can influence Alzheimer's disease risk, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Goldstein, Lee E. — Boston University Medical Campus
- Study coordinator: Goldstein, Lee E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.