How toxic metals affect Alzheimer's disease in aging mice
Official title: Impact of Toxic Metal Exposures in Novel Genetic Mouse Models of Late-Onset Alzheimer's Disease
Funded at Boston University Medical Campus · NIH-10901030 · Data updated 2026-11-12
This study is looking at how long-term exposure to harmful metals like lead and arsenic might affect the risk of developing late-onset Alzheimer's disease, using special mouse models to understand the connection better, which could help people learn more about how their environment impacts their brain health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $822,643 |
| NIH project number | 1R56AG083940-01 |
| Project ID | NIH-10901030 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include older adults who may have been exposed to toxic metals and are at risk for Alzheimer's disease.
✕Less likely to help
Patients who are not at risk for Alzheimer's disease or have no history of exposure to toxic metals may not receive benefit from this research.
What this research studies
This research investigates the impact of chronic exposure to toxic metals like lead, cadmium, and arsenic on the development of late-onset Alzheimer's disease (LOAD) using innovative mouse models. By examining the interactions between genetic factors and environmental exposures, the study aims to uncover the molecular mechanisms that contribute to the risk of developing LOAD. The findings could help identify at-risk populations and inform strategies for prevention and intervention. Patients may benefit from insights into how environmental factors influence their health outcomes related to Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for Alzheimer's disease linked to environmental toxicants.
How similar studies have gone: Previous research has shown that environmental factors can influence Alzheimer's disease risk, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Goldstein, Lee E. — Boston University Medical Campus
- Study coordinator: Goldstein, Lee E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.