How touch sensitivity affects brain development in autism.
The Effects of Somatosensory Experience on Brain Development and Function in Autism Spectrum Disorders
This study is looking at how problems with touch sensitivity in people with autism might affect their brain development and social skills, using mouse models to find out more about these connections and hopefully discover new ways to help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10872225 on NIH RePORTER |
What this research studies
This research investigates how abnormalities in touch sensitivity, particularly in individuals with autism spectrum disorders (ASD), influence brain development and function. The study focuses on the role of peripheral somatosensory neurons, which are responsible for processing touch sensations, and how their dysfunction may lead to social interaction challenges. By examining various ASD mouse models, the research aims to uncover the mechanisms linking sensory neuron issues to brain circuit development and social behavior deficits. This could provide insights into new therapeutic approaches for improving outcomes in individuals with ASD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 21 years old diagnosed with autism spectrum disorders.
Not a fit: Patients without a diagnosis of autism spectrum disorders or those over 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new interventions that improve social communication and reduce sensory sensitivities in individuals with autism.
How similar studies have performed: Previous research has shown promising results in understanding the role of sensory processing in autism, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Orefice, Lauren Lynn — Massachusetts General Hospital
- Study coordinator: Orefice, Lauren Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.