How toluene affects blood flow in the brain
Ionic mechanisms of toluene cerebrovascular actions
This study looks at how toluene, a common solvent, affects blood flow in the brain when someone is exposed to it, aiming to understand how it can cause serious problems and find ways to reduce its harmful effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11030784 on NIH RePORTER |
What this research studies
This research investigates the effects of toluene, a common solvent, on blood flow in the brain, particularly during acute intoxication. It aims to understand how toluene causes constriction of cerebral arteries, which can lead to serious neurological issues. By studying both animal models and cellular mechanisms, the research seeks to identify the specific ion channels involved in this process. The findings could provide insights into the biological targets affected by toluene and help develop strategies to mitigate its harmful effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced acute toluene intoxication or are at risk of exposure to toluene.
Not a fit: Patients who have not been exposed to toluene or do not have related neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for individuals suffering from the neurological consequences of toluene exposure.
How similar studies have performed: While the specific mechanisms of toluene's effects on cerebral blood flow are not well-studied, similar research on other substances affecting brain circulation has shown promising results.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Dopico, Alex M. — University of Tennessee Health Sci Ctr
- Study coordinator: Dopico, Alex M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.