How Toll receptors influence cell shape and energy during tissue development
Official title: Control of epithelial morphology and bioenergetics by Toll receptors during dynamic tissue remodeling
Funded at University of Arkansas at Fayetteville · NIH-10913616 · Data updated 2026-11-12
This study is looking at how certain receptors in cells help shape and energize tissues as they grow, using fruit flies to learn more about how these processes work, which could help us understand how our bodies develop properly.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arkansas at Fayetteville NIH-funded |
| Lab location | 1 site (Fayetteville, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $311,353 |
| NIH project number | 5R01GM147372-02 |
| Project ID | NIH-10913616 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to epithelial tissue development or remodeling, such as certain birth defects.
✕Less likely to help
Patients with conditions unrelated to epithelial tissue development or those who do not have any developmental disorders may not benefit from this research.
What this research studies
This research investigates the role of Toll receptors in controlling the shape and energy dynamics of epithelial cells during tissue development. By studying model organisms like Drosophila, the researchers aim to understand how these receptors affect cell behavior and organization. They will utilize advanced techniques, including CRISPR/Cas9, to manipulate genes and observe changes in cell morphology and bioenergetics in living embryos. This work could provide insights into the fundamental processes of tissue remodeling, which is crucial for proper development.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating developmental disorders and improving tissue regeneration.
How similar studies have gone: While the specific focus on Toll receptors in this context is novel, similar research has shown success in understanding cell behavior and tissue development through genetic manipulation.
Where this research is happening
-
University of Arkansas at Fayetteville
Fayetteville, United States Active
Researchers
- Principal investigator: Pare, Adam Christopher — University of Arkansas at Fayetteville
- Study coordinator: Pare, Adam Christopher
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.