How 'tobacco-free' oral nicotine pouches affect perceptions and use in smokers and non-nicotine users

Novel "Tobacco-Free" Oral Nicotine Pouches: The impact of Product Features and Marketing Influences on Abuse Liability, Perceptions, and Use Behavior in Smokers and Non-Nicotine Users

NIH-funded research Johns Hopkins University · NIH-11303298

This project looks at how 'tobacco-free' nicotine pouches and their advertising influence what adults who smoke or who don't use nicotine think about and how they might use these products.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionJohns Hopkins University NIH-funded
Lab location1 site (Baltimore, United States)
Project IDNIH-11303298 on NIH RePORTER

What this research studies

From a participant's point of view, researchers will use human lab tests, real-world marketing monitoring, and online experiments to identify which product features and ads make these pouches appealing. Lab visits will measure nicotine exposure and immediate responses, marketing surveillance will track how the products are promoted and sold, and web-based experiments will test how labels, flavors, and 'tobacco-free' claims change perceptions and interest. The team will compare adults who currently smoke with adults who do not use nicotine to see which features encourage switching versus starting use. The work is designed to produce clear, practical findings that regulators and public-health groups can use.

Who could benefit from this research

Good fit: Adults who currently smoke and adults who do not use nicotine (typically adults meeting the legal purchase age) are the main groups who may be invited to join lab visits or online experiments.

Not a fit: People under the legal age for tobacco product purchase (minors), pregnant people, and those not represented in the study groups may not receive direct benefit or be eligible to participate.

Why it matters

Potential benefit: If successful, the project could help regulators limit misleading marketing to protect young people and guide safer options for adult smokers who might switch.

How similar studies have performed: Industry data show these pouches can deliver nicotine similar to smokeless tobacco, but independent public research on their marketing effects and appeal is limited, so this combined lab-and-marketing approach is relatively new.

Where this research is happening

Baltimore, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.