How TNF affects a new cancer treatment using viruses
Official title: Impact of TNF on Oncolytic Virotherapy
Funded at University of New Mexico Health Scis Ctr · NIH-10913584 · Data updated 2026-11-12
This study is looking at how a substance called TNF can help make a cancer treatment using viruses work better, and it aims to find ways to block TNF to improve results and lessen side effects for people with solid tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $416,256 |
| NIH project number | 5R01CA276134-02 |
| Project ID | NIH-10913584 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with solid tumors who are considering or currently undergoing oncolytic virotherapy.
✕Less likely to help
Patients with non-solid tumors or those who do not qualify for oncolytic virotherapy may not benefit from this research.
What this research studies
This research investigates the role of TNF in enhancing the effectiveness of oncolytic virotherapy, a promising cancer treatment that uses viruses to stimulate the immune system against tumors. The study aims to understand how TNF influences the immune response during therapy and to explore ways to block TNF to improve treatment outcomes and reduce side effects. By using a modified virus that expresses a soluble PD1 inhibitor and an IL12 fusion protein, the researchers hope to identify mechanisms that can lead to better responses in patients with solid tumors. This approach could potentially transform how oncolytic virotherapy is applied in clinical settings.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer cancer treatments for patients undergoing oncolytic virotherapy.
How similar studies have gone: This research is exploring a novel approach, as no other studies have demonstrated the positive impact of TNF blockade on oncolytic virotherapy.
Where this research is happening
-
University of New Mexico Health Scis Ctr
Albuquerque, United States Active
Researchers
- Principal investigator: Bartee, Eric Carter — University of New Mexico Health Scis Ctr
- Study coordinator: Bartee, Eric Carter
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.