How TMEM106B gene changes and protein clumps relate to Alzheimer’s, LATE, and frontotemporal dementia
Investigating the role of TMEM106b genetics and pathology in Alzheimer’s disease, LATE and FTLD
This project looks at whether changes in the TMEM106B gene and buildup of its protein in the brain are linked to Alzheimer's disease, LATE, and frontotemporal dementia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-11173602 on NIH RePORTER |
What this research studies
You will hear about research that uses a new antibody to spot TMEM106B protein filaments in brain tissue from people with Alzheimer's, LATE, and FTLD. The team compares genetic variants, especially the rs3173615 variant, to see if people with the risk form have more TMEM106B accumulation. They analyze insoluble protein fractions from patient samples and run lab studies to understand how the gene change might cause protein clumping. Results will be compared across patient samples and experimental models to point toward possible markers or targets for future tests or treatments.
Who could benefit from this research
Good fit: Ideal candidates are people diagnosed with Alzheimer's disease, LATE, or frontotemporal lobar degeneration (FTLD), or individuals willing to donate brain tissue or other biospecimens for research.
Not a fit: Patients looking for an immediate treatment effect should not expect direct clinical benefit from this basic and translational research study.
Why it matters
Potential benefit: If successful, this work could identify new biomarkers or drug targets that help diagnose or treat Alzheimer’s, LATE, and frontotemporal dementia.
How similar studies have performed: TMEM106B filaments were only recently discovered in neurodegenerative disease samples, so this project builds on new but still early findings rather than an established clinical approach.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Petrucelli, Leonard — Mayo Clinic Jacksonville
- Study coordinator: Petrucelli, Leonard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.