How tissue structure and remodeling affect tissue health and aneurysm growth
Integrate Data-Driven Modeling and Multi-scale Measures Towards Tissue Function
['FUNDING_R01'] · LEHIGH UNIVERSITY · NIH-11194525
This project uses lab measurements and computer models to learn how differences in tissue structure change tissue strength and may drive aneurysm growth in people.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LEHIGH UNIVERSITY (nih funded) |
| Locations | 1 site (BETHLEHEM, UNITED STATES) |
| Trial ID | NIH-11194525 on ClinicalTrials.gov |
What this research studies
From a patient's point of view, the team will measure how cells and the surrounding matrix interact and change the mechanical properties of tissues. They will run lab experiments on cells and tissue samples, collect multi-scale measurements, and build computer models that combine physics-based rules with machine learning. The goal is to create a 'digital twin' that simulates how tissues remodel and degenerate over time and to link those changes to aneurysm growth. This work connects small-scale cell signaling and matrix changes to whole-tissue behavior to improve understanding of tissue failure.
Who could benefit from this research
Good fit: People with known aneurysms, vascular tissue weakness, or those willing to provide tissue samples or clinical imaging/data would be the most relevant candidates to contribute to this research.
Not a fit: People without tissue-structural problems or those needing immediate emergency intervention are unlikely to receive direct benefit from this basic and modeling-focused work.
Why it matters
Potential benefit: If successful, this work could help predict who is at greater risk for aneurysm growth and support more personalized monitoring or treatment planning.
How similar studies have performed: Laboratory tissue mechanics tests and computational models have informed prior research, but integrating multi-scale experiments with data-driven 'digital twin' models for aneurysm prediction is a novel approach.
Where this research is happening
BETHLEHEM, UNITED STATES
- LEHIGH UNIVERSITY — BETHLEHEM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YU, YUE — LEHIGH UNIVERSITY
- Study coordinator: YU, YUE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.