How tissue mechanics influences cancer growth and spread
Official title: Tissue mechanics reprograms the tissue to malignancy and metastasis
Funded at University of California, San Francisco · NIH-10909887 · Data updated 2026-11-12
This study is looking at how the stiffness of tissue can influence cancer growth and behavior, using special lab techniques to mimic tumors, with the hope of finding new ways to prevent and treat aggressive cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2020 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $907,698 |
| NIH project number | 5R35CA242447-05 |
| Project ID | NIH-10909887 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with aggressive forms of cancer, particularly those with chronic inflammation or tissue stiffness.
✕Less likely to help
Patients with early-stage cancer or those without significant tissue stiffness or inflammation may not benefit from this research.
What this research studies
This research investigates how the physical properties of tissue, particularly the extracellular matrix (ECM), affect the development and progression of cancer. By studying the relationship between tissue stiffness and cellular behavior, the research aims to uncover the molecular mechanisms that lead to malignancy. The approach includes using advanced 3D cell culture techniques to simulate the tumor environment and identify potential biomarkers for cancer risk. The ultimate goal is to develop new drug targets for preventing and treating aggressive tumors.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cancer progression and improving treatment outcomes for patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of the extracellular matrix in cancer, suggesting that this approach could lead to significant advancements in cancer treatment.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Weaver, Valerie Marie — University of California, San Francisco
- Study coordinator: Weaver, Valerie Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.