How tissue mechanics influences cancer growth and spread
Tissue mechanics reprograms the tissue to malignancy and metastasis
This study is looking at how the stiffness of tissue can influence cancer growth and behavior, using special lab techniques to mimic tumors, with the hope of finding new ways to prevent and treat aggressive cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10909887 on NIH RePORTER |
What this research studies
This research investigates how the physical properties of tissue, particularly the extracellular matrix (ECM), affect the development and progression of cancer. By studying the relationship between tissue stiffness and cellular behavior, the research aims to uncover the molecular mechanisms that lead to malignancy. The approach includes using advanced 3D cell culture techniques to simulate the tumor environment and identify potential biomarkers for cancer risk. The ultimate goal is to develop new drug targets for preventing and treating aggressive tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with aggressive forms of cancer, particularly those with chronic inflammation or tissue stiffness.
Not a fit: Patients with early-stage cancer or those without significant tissue stiffness or inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cancer progression and improving treatment outcomes for patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of the extracellular matrix in cancer, suggesting that this approach could lead to significant advancements in cancer treatment.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Weaver, Valerie Marie — University of California, San Francisco
- Study coordinator: Weaver, Valerie Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.